سمیت زیستی نانوذرات نقره

نوع مقاله : علمی - پژوهشی

نویسنده

عضو هیئت علمی، مرکز تحقیقات پروتئین و دانشکده انرژی و فناوری های نوین، دانشگاه شهید بهشتی

چکیده

   امروزه نانوذرات سنتزی گستره وسیعی از ذرات با ویژگی‌های منحصر‌به‌فرد را دربر می‌گیرند و کاربردهای زیادی در حوزه نانوتکنولوژی  دارند. خواص ویژه نانوذرات و برهمکنش آنها با مولکول‌های زیستی توجه بسیاری از محققان را به خود جلب کرده است. این ذرات به دلیل اندازه کوچک و ویژگی‌های منحصربه‌فرد، قابلیت استفاده در علوم مختلف، مخصوصاً علوم زیستی را دارند. بررسی‌های گذشته در حوزه نانوذرات نشان می‌دهند که به دلیل عدم وجود یک مدل منطقی از برهمکنش این ذرات با مولکول‌های زیستی، تاکنون از روش‌های آزمایش و خطا به ویژگی‌های یک نانوذره و اثرات آن بر محیط واکنش و مولکول‌های حاضر در آن محیط پی می‌بردند. به دلیل ورود این ذرات به گیاهان و بدن جانوران، و مخصوصاً استفاده روزافزون آنها در محصولات مورد استفاده‌ انسان، بررسی اثرات ایجادشده توسط این ذرات بر مولکول‌ها و میزبان‌های زیستی ضروری به نظر می‌رسد. ، در این مقاله مروری اثرات سمی نانو ذرات نقره در محیط‌های زیستی و آثار مخرب آنها بررسی شد و نتایج پژوهش‌های بین‌المللی در حوزه‌های مختلفی از جمله مولکول‌های زیستی، میکروارگانیسم‌ها، گیاهان، جانوران و انسان مرور شده است. در این میان یافته‌های مرتبط با تریپسین و آلبومین سرم خونی انسانی در حوزه رفتارهای مولکولی، باکتری‌های   Staphylococcus aureus و  Bacillus  thurigiensis در زیرمجموعه باکتریایی و گیاه Oryza sativa L. (برنج)،  از نظر ریخت‌شناسی و پرتئومیکس به‌طور ویژه مورد توجه قرار گرفته‌اند. 

کلیدواژه‌ها

عنوان مقاله [English]

Nanotoxicity: Silver Nano Particles

نویسنده [English]

  • Fatemeh Mirzajani
Faculty of New Technologies Engineering (NET) and Protein Research Center (PRC), Shahid Beheshti University, G.C., Tehran, Iran.
چکیده [English]

Nanoparticles with a wide range of unique features have been allocated many applications in the field of nanotechnology. Their special properties and their interaction with biological molecules have grabbed the attention of many researchers. These particles, because of their small size and unique characteristics, can be used in various fields, especially the life sciences. Because the lack of any logical model of nanoparticle and biomolecule interaction, their properties and influences on the environment have been evaluated using various separate and non-comparable studies. Nanoparticles interact with plants, animals, and humans and have various and essential impacts on them and these should be considered. The aim of this article is to conduct a morphological and proteomic study of the interaction of biomolecular, bacterial and plant models with silver nanoparticles. The findings are associated with trypsin and human blood serum albumin (as a molecular model), Staphylococcus aureus and Bacillus Thurigiensis (as bacterial models) and Oryza sativa L. (rice) as a plant model.

کلیدواژه‌ها [English]

  • Proteomics
  • Morphological study
  • Silver Nanoparticles
  • S. aureus ، B. Thurigiensis ، Oryza sativa L

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فصلنامه علوم محیطی
دوره 14، شماره 2
تیر 1395
صفحه 129-138

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